Title

Ultrastructural Changes in the Mitochondria of Intestinal Epithelium of Rodents Treated with Methylglyoxal-bis(guanylhydrazone)

Document Type

Article

Publication Source

Cancer Research

Publication Date

1983-02-01

Volume

43

Issue

2

First Page

646

Last Page

652

Abstract

Ultrastructural studies of rats or mice treated for 24 hr with a toxic dose (100 mg/kg) of methylglyoxal-bis(guanylhydrazone) revealed the presence of damaged mitochondria in the crypt cells of the intestinal epithelium. Mitochondria were severely swollen and electron lucent, and appeared to be similar to those observed previously in a variety of cell types treated in vitro and in vivo with methylglyoxal-bis(guanylhydrazone). Since thymidine incorporation into the intestine was not found to be decreased until after 24 hr, it is concluded that the mitochondrial damage of methylglyoxal-bis(guanylhydrazone) could be responsible for the antiproliferative toxicities of the drug. © 1983, American Association for Cancer Research. All rights reserved.

This document is currently not available here.

Share

COinS